Isolation of 3β, 7α-Dihydroxychol-5-en-24-oic and 3β, 7α-Dihydroxychol-4-en-24-oic Acids from Human Bile
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چکیده
منابع مشابه
Cholestenoic acids regulate motor neuron survival via liver X receptors.
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we evaluated the cholestenoic acid profile of mammalian cerebrospinal fluid (CSF) and determined that specific cholestenoic acids activate the liver X receptors (LXRs), enhance islet-1 expression in zeb...
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As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels have been linked to prognosis. More than 40 different sterols were quantified in serum and cerebrospinal fluid (CSF) from ALS patients and healthy ...
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In the title compound, C(34)H(51)NO(2), the dihedral angle between the planes of the phenyl ring and the carbonyl group is 9.30 (2)°. No significant inter-molecular inter-actions are observed in the crystal structure. The C(5)H(11) fragment is disordered over two positions with site occupancies of 0.611 (6) and 0.389 (6).
متن کامل3β-Chlorocholest-5-en-7-one
The title compound, C(27)H(43)ClO, is a steroid derivative composed of a saturated carbon fused-ring framework with an alkyl side chain. The A and C rings have chair conformations and the B and D rings assume half-chair conformations. The cholesterol side chain is fully extended with a gauche, trans conformation of the terminal methyl groups. In the crystal structure, the molecules are aligned ...
متن کامل2′-Methylpyrazolo[4′,3′:16,17]androst-5-en-3β-ol
In the title compound, C(21)H(30)N(2)O, there are five fused rings. The A and C rings adopt chair conformations, ring B adopts an 8β,9α-half-chair conformation and ring D adopts a 14α-envelope conformation. The pyrazole ring is planar. Inter-molecular O-H⋯N hydrogen bonds [H⋯N = 1.88 (5) Å] help to stabilize the crystal structure. The absolute structure was deduced from those of the starting ma...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy
سال: 1976
ISSN: 0021-4280
DOI: 10.2183/pjab1945.52.453